BAIT
IFIT3
CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, RP11-149I23.4
interferon-induced protein with tetratricopeptide repeats 3
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
YBX3
CSDA, CSDA1, DBPA, ZONAB
Y box binding protein 3
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IC]
- cellular hyperosmotic response [IMP]
- cellular response to tumor necrosis factor [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [IMP]
- negative regulation of necroptotic process [IMP]
- positive regulation of cytoplasmic translation [ISS]
- response to cold [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
Antiviral innate immunity relies on the recognition of microbial structures. One such structure is viral RNA that carries a triphosphate group on its 5' terminus (PPP-RNA). By an affinity proteomics approach with PPP-RNA as the 'bait', we found that the antiviral protein IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) mediated binding of a larger protein complex containing other IFIT family ... [more]
Nat. Immunol. Jul. 01, 2011; 12(7);624-30 [Pubmed: 21642987]
Throughput
- High Throughput
Additional Notes
- interaction seen in cells exposed to IFN-alpha/beta
Curated By
- BioGRID