BAIT
SPT10
CRE1, SUD1, L000002035, YJL127C
Putative histone acetylase with a role in transcriptional silencing; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
GO Process (6)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
SAM37
MAS37, PET3027, TOM37, SAM complex subunit SAM37, L000002841, L000003251, YMR060C
Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
GO Process (3)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Cell-Cycle Perturbations Suppress the Slow-Growth Defect of spt10Δ Mutants in Saccharomyces cerevisiae.
Spt10 is a putative acetyltransferase of that directly activates the transcription of histone genes. Deletion of causes a severe slow growth phenotype, showing that Spt10 is critical for normal cell division. To gain insight into the function of Spt10, we identified mutations that impair or improve the growth of null mutants. Mutations that cause lethality in combination with include particular ... [more]
G3 (Bethesda) Mar. 01, 2013; 3(3);573-83 [Pubmed: 23450643]
Throughput
- Low Throughput
Ontology Terms
- inviable (APO:0000112)
Curated By
- BioGRID