BAIT
ATF2
CRE-BP1, CREB-2, CREB2, HB16, TREB7
activating transcription factor 2
GO Process (26)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- chromatin organization [TAS]
- histone acetylation [IDA]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IMP]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- regulation of transcription from RNA polymerase II promoter [IC]
- regulation of transcription, DNA-templated [IMP]
- response to osmotic stress [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [IC]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IC]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription factor binding transcription factor activity [IC]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- cAMP response element binding [IDA]
- cAMP response element binding protein binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- histone acetyltransferase activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [TAS]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IC]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription factor binding transcription factor activity [IC]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- cAMP response element binding [IDA]
- cAMP response element binding protein binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- histone acetyltransferase activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPD1
CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13
heat shock 60kDa protein 1 (chaperonin)
GO Process (24)
GO Function (11)
GO Component (16)
Gene Ontology Biological Process
- 'de novo' protein folding [ISS]
- ATP catabolic process [ISS]
- B cell activation [IDA]
- B cell cytokine production [IDA]
- B cell proliferation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- T cell activation [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- chaperone-mediated protein complex assembly [ISS]
- isotype switching to IgG isotypes [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell mediated immune response to tumor cell [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-gamma production [IDA, ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage activation [IDA]
- protein maturation [ISS]
- protein refolding [IDA]
- protein stabilization [IMP, ISS]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
Gene Ontology Cellular Component
- cell surface [IDA]
- coated pit [IDA]
- coated vesicle [IDA]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- lipopolysaccharide receptor complex [IDA]
- membrane [IDA]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- protein complex [IDA]
- secretory granule [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The ability of ATF2 to reach the mitochondria is determined by PKCε, which directs ATF2 nuclear localization. ... [more]
Cell Feb. 03, 2012; 148(3);543-55 [Pubmed: 22304920]
Throughput
- High Throughput
Ontology Terms
- squamous cell carcinoma cell line (BTO:0002024) [squamous cell carcinoma (DOID:1749)]
Additional Notes
- exogenous expression of bait
- table 1, figure 2.
Curated By
- BioGRID