BAIT
AHI1
1700015F03Rik, Ahi-1, D10Bwg0629e
Abelson helper integration site 1
GO Process (24)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- cellular protein localization [IGI]
- central nervous system development [IGI]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- cloaca development [IGI]
- heart looping [IGI]
- hindbrain development [IGI]
- morphogenesis of a polarized epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- otic vesicle development [IGI]
- photoreceptor cell outer segment organization [IGI, IMP]
- positive regulation of gene expression [IMP]
- positive regulation of polarized epithelial cell differentiation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pronephric nephron tubule morphogenesis [IGI]
- protein localization to organelle [IMP]
- regulation of behavior [IMP]
- retina development in camera-type eye [IMP]
- retina layer formation [IGI]
- specification of axis polarity [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
- vesicle targeting [IMP]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TUBA1B
Tuba2
tubulin, alpha 1B
GO Process (1)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID