BAIT
AHI1
1700015F03Rik, Ahi-1, D10Bwg0629e
Abelson helper integration site 1
GO Process (24)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- cellular protein localization [IGI]
- central nervous system development [IGI]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- cloaca development [IGI]
- heart looping [IGI]
- hindbrain development [IGI]
- morphogenesis of a polarized epithelium [IMP]
- negative regulation of apoptotic process [IMP]
- otic vesicle development [IGI]
- photoreceptor cell outer segment organization [IGI, IMP]
- positive regulation of gene expression [IMP]
- positive regulation of polarized epithelial cell differentiation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pronephric nephron tubule morphogenesis [IGI]
- protein localization to organelle [IMP]
- regulation of behavior [IMP]
- retina development in camera-type eye [IMP]
- retina layer formation [IGI]
- specification of axis polarity [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
- vesicle targeting [IMP]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA5
AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP, RP23-446N16.1
heat shock protein 5
GO Process (15)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of signaling protein activity involved in unfolded protein response [IMP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [IDA]
- cerebellar Purkinje cell layer development [IMP]
- cerebellum structural organization [IMP]
- maintenance of protein localization in endoplasmic reticulum [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of embryonic development [TAS]
- positive regulation of protein ubiquitination [IMP]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to endoplasmic reticulum stress [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [IDA]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [IDA]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [ISO]
- midbody [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID