BAIT
NPHP1
RP23-189N15.5
nephronophthisis 1 (juvenile) homolog (human)
GO Process (5)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSP90AB1
90kDa, AL022974, C81438, Hsp84, Hsp84-1, Hsp90, Hspcb
heat shock protein 90 alpha (cytosolic), class B member 1
GO Process (7)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- cellular response to interleukin-4 [IDA]
- negative regulation of neuron apoptotic process [ISO]
- placenta development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID