BAIT
NPHP1
RP23-189N15.5
nephronophthisis 1 (juvenile) homolog (human)
GO Process (5)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
C3
AI255234, ASP, HSE-MSF, Plp
complement component 3
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- blood coagulation [ISO]
- complement activation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of G-protein coupled receptor protein signaling pathway [ISO]
- positive regulation of activation of membrane attack complex [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic cell clearance [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of glucose transport [ISO]
- positive regulation of lipid storage [ISO]
- positive regulation of phagocytosis [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of type IIa hypersensitivity [IMP]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of triglyceride biosynthetic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID