BAIT
NPHP4
4930564O18Rik, nmf192, RP23-352D7.1
nephronophthisis 4 (juvenile) homolog (human)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
JUP
Ctnng, D930025P04Rik, PG, RP23-392I3.6
junction plakoglobin
GO Process (17)
GO Function (7)
GO Component (21)
Gene Ontology Biological Process
- bundle of His cell to Purkinje myocyte communication [ISO]
- cell adhesion [IDA]
- cell migration [ISO]
- cellular response to indole-3-methanol [ISO]
- desmosome assembly [IMP, ISO]
- detection of mechanical stimulus [ISO]
- establishment of protein localization to plasma membrane [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein heterooligomerization [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of nucleic acid-templated transcription [IBA]
- single organismal cell-cell adhesion [IMP, ISO]
- skin development [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- actin cytoskeleton [ISO]
- apicolateral plasma membrane [ISO]
- catenin complex [IBA, ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytosol [IDA]
- desmosome [IDA, IMP, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- gamma-catenin-TCF7L2 complex [ISO]
- intercalated disc [ISO]
- intermediate filament [IDA]
- lateral plasma membrane [ISO]
- membrane [IDA]
- nucleus [IBA, ISO]
- plasma membrane [ISO]
- protein-DNA complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID