BAIT
CEP290
BC004690, Nphp6, b2b1454Clo, b2b1752Clo
centrosomal protein 290
GO Process (9)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- establishment or maintenance of cell polarity [IMP]
- positive regulation of intracellular protein transport [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein transport [IMP]
- regulation of cAMP metabolic process [IMP]
- regulation of establishment of protein localization [ISO]
- retina development in camera-type eye [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KRT6A
CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3
keratin 6A
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID