BAIT
IQCB1
6820449I09Rik, AV128382, NPHP5
IQ calmodulin-binding motif containing 1
GO Process (3)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RIC8
AI114950, RIC-8, Ric8a
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA]
- basement membrane organization [IMP]
- cell migration involved in gastrulation [IMP]
- cell-cell adhesion involved in gastrulation [IMP]
- gastrulation [IMP]
- in utero embryonic development [IMP]
- positive regulation of GTPase activity [IBA, ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- response to light stimulus [IMP]
- vasculature development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID