BAIT
IQCB1
6820449I09Rik, AV128382, NPHP5
IQ calmodulin-binding motif containing 1
GO Process (3)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HADHA
C77020, Mtpa
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
GO Process (4)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID