BAIT
IQCB1
6820449I09Rik, AV128382, NPHP5
IQ calmodulin-binding motif containing 1
GO Process (3)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPH1
105kDa, AI790491, Hsp105, Hsp110, hsp-E7I
heat shock 105kDa/110kDa protein 1
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- chaperone mediated protein folding requiring cofactor [IDA]
- establishment of protein localization to mitochondrion [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [TAS]
- positive regulation of MHC class I biosynthetic process [TAS]
- positive regulation of NK T cell activation [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of microtubule cytoskeleton organization [NAS]
- regulation of p38MAPK cascade [IGI]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID