BAIT
RPGRIP1L
1700047E16Rik, 4931437C01, Ftm, Nphp8
Rpgrip1-like
GO Process (25)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- brain development [IMP]
- camera-type eye development [IMP]
- cerebellum development [IMP]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- cochlea development [IMP]
- corpus callosum development [IMP]
- determination of left/right symmetry [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- establishment of planar polarity [IMP]
- establishment or maintenance of cell polarity [IMP]
- head development [IMP]
- in utero embryonic development [IMP]
- kidney development [IMP]
- lateral ventricle development [IMP]
- limb morphogenesis [IMP]
- liver development [IMP]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- neural tube patterning [IMP]
- nose development [IMP]
- olfactory bulb development [IMP]
- pericardium development [IMP]
- regulation of smoothened signaling pathway [IMP]
- telencephalon development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RPS3
D7Ertd795e, Rs_3
ribosomal protein S3
GO Process (7)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IBA, ISO]
- DNA repair [IBA]
- cytoplasmic translation [IBA]
- negative regulation of DNA repair [ISO]
- positive regulation of DNA N-glycosylase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
Gene Ontology Molecular Function- DNA-(apurinic or apyrimidinic site) lyase activity [ISO]
- NF-kappaB binding [ISO]
- damaged DNA binding [IBA, ISO]
- enzyme binding [ISO]
- mRNA binding [ISO]
- oxidized purine nucleobase lesion DNA N-glycosylase activity [IBA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- structural constituent of ribosome [IBA, ISO]
- DNA-(apurinic or apyrimidinic site) lyase activity [ISO]
- NF-kappaB binding [ISO]
- damaged DNA binding [IBA, ISO]
- enzyme binding [ISO]
- mRNA binding [ISO]
- oxidized purine nucleobase lesion DNA N-glycosylase activity [IBA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- structural constituent of ribosome [IBA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID