BAIT
IQCB1
6820449I09Rik, AV128382, NPHP5
IQ calmodulin-binding motif containing 1
GO Process (3)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
AIFM1
AIF, AIFsh2, Hq, Pdcd8, RP23-35N5.1
apoptosis-inducing factor, mitochondrion-associated 1
GO Process (12)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- apoptotic mitochondrial changes [TAS]
- apoptotic process [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- mitochondrial respiratory chain complex I assembly [ISO]
- neuron apoptotic process [IGI]
- neuron differentiation [ISO]
- oxidation-reduction process [ISO]
- positive regulation of apoptotic process [TAS]
- positive regulation of cell death [IMP]
- regulation of apoptotic DNA fragmentation [IGI]
- response to oxidative stress [TAS]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID