BAIT
NPHP4
4930564O18Rik, nmf192, RP23-352D7.1
nephronophthisis 4 (juvenile) homolog (human)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GFAP
AI836096
glial fibrillary acidic protein
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- astrocyte development [IGI]
- extracellular matrix organization [IMP]
- intermediate filament organization [IGI, IMP]
- intermediate filament-based process [IMP]
- long-term synaptic potentiation [IMP]
- negative regulation of neuron projection development [IGI, IMP]
- neuron projection regeneration [IMP]
- positive regulation of Schwann cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of neurotransmitter uptake [IMP]
- response to wounding [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID