BAIT
NPHP4
4930564O18Rik, nmf192, RP23-352D7.1
nephronophthisis 4 (juvenile) homolog (human)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSP90AA1
86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4, RP23-60K23.1
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (13)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [ISO]
- nitric oxide biosynthetic process [TAS]
- positive regulation of cell size [ISO]
- positive regulation of cytotoxic T cell differentiation [TAS]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of protein import into nucleus, translocation [ISO]
- protein import into mitochondrial outer membrane [ISO]
- protein refolding [TAS]
- regulation of catalytic activity [ISO]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO, TAS]
- extracellular matrix [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID