BAIT
NPHP4
4930564O18Rik, nmf192, RP23-352D7.1
nephronophthisis 4 (juvenile) homolog (human)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKDC
AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
protein kinase, DNA activated, catalytic polypeptide
GO Process (36)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell lineage commitment [IMP]
- T cell differentiation in thymus [IMP]
- T cell lineage commitment [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cellular response to insulin stimulus [ISO]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [IMP]
- ectopic germ cell programmed cell death [IMP]
- heart development [IGI]
- immunoglobulin V(D)J recombination [IMP]
- immunoglobulin production [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- lymphocyte differentiation [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of response to gamma radiation [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of developmental growth [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of immune system process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pro-B cell differentiation [IMP]
- protein destabilization [IDA]
- protein phosphorylation [IDA]
- regulation of circadian rhythm [IMP]
- response to gamma radiation [IMP]
- signal transduction involved in mitotic G1 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
- spleen development [ISO]
- telomere maintenance [IMP]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID