BAIT
NPHP4
4930564O18Rik, nmf192, RP23-352D7.1
nephronophthisis 4 (juvenile) homolog (human)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDH2
CDHN, N-cadherin, Ncad
cadherin 2
GO Process (19)
GO Function (9)
GO Component (15)
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell-cell adhesion mediated by cadherin [IDA]
- glial cell differentiation [IDA]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of canonical Wnt signaling pathway [IGI]
- neuronal stem cell maintenance [IDA]
- positive regulation of MAPK cascade [IGI]
- protein heterooligomerization [ISO]
- regulation of Rho protein signal transduction [ISO]
- regulation of axonogenesis [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [ISO]
- single organismal cell-cell adhesion [ISO]
- striated muscle cell differentiation [IGI]
- synapse assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- adherens junction [IDA]
- apical plasma membrane [IDA]
- catenin complex [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [IDA]
- membrane [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: "NPHP1-4-8" functioning at the ... [more]
Cell May. 13, 2011; 145(4);513-28 [Pubmed: 21565611]
Throughput
- High Throughput
Curated By
- BioGRID