BAIT
PEX14
NAPP2, PBD13A, Pex14p, dJ734G22.2
peroxisomal biogenesis factor 14
GO Process (12)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- microtubule anchoring [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of protein homotetramerization [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- peroxisome organization [IGI, ISS]
- peroxisome transport along microtubule [IDA]
- protein complex assembly [IDA]
- protein homooligomerization [IDA]
- protein import into peroxisome matrix [IMP]
- protein import into peroxisome matrix, substrate release [IDA]
- protein import into peroxisome matrix, translocation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM2
CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
dynamin 2
GO Process (20)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [NAS]
- GTP catabolic process [NAS, TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- endocytosis [NAS]
- membrane organization [TAS]
- negative regulation of membrane tubulation [IDA]
- neuron projection morphogenesis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of transcription, DNA-templated [NAS]
- post-Golgi vesicle-mediated transport [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [ISS]
- regulation of axon extension [ISS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of transcription, DNA-templated [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic vesicle transport [NAS]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
PEX14 is required for microtubule-based peroxisome motility in human cells.
We have established a procedure for isolating native peroxisomal membrane protein complexes from cultured human cells. Protein-A-tagged peroxin 14 (PEX14), a central component of the peroxisomal protein translocation machinery was genomically expressed in Flp-In-293 cells and purified from digitonin-solubilized membranes. Size-exclusion chromatography revealed the existence of distinct multimeric PEX14 assemblies at the peroxisomal membrane. Using mass spectrometric analysis, almost all ... [more]
J. Cell. Sci. May. 15, 2011; 124(0);1759-68 [Pubmed: 21525035]
Throughput
- Low Throughput
Curated By
- BioGRID