BAIT

GGA1

RP1-37E16.3
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Alzheimer's Disease Project
UPS Project
GO Process (1)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ARF1

RP23-192P17.1
ADP-ribosylation factor 1
Mus musculus

Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.

Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S

GGAs are critical for trafficking soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes through interactions with TGN-sorting receptors, ADP-ribosylation factor (ARF) and clathrin. ARF-GTP bound to TGN membranes recruits its effector GGA by binding to the GAT domain, thus facilitating recognition of GGA for cargo-loaded receptors. Here we report the X-ray crystal structures of the human GGA1-GAT domain and ... [more]

Nat. Struct. Biol. May. 01, 2003; 10(5);386-93 [Pubmed: 12679809]

Throughput

  • Low Throughput

Additional Notes

  • N-terminal region of the human GGA1 GAT domain complexed with mouse ARF1 Q71L mutant protein lacking the N-terminal 17 residues

Curated By

  • BioGRID