BAIT
CSNK2A1
CK2A1, CKII, CSNK2A3
casein kinase 2, alpha 1 polypeptide
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- chaperone-mediated protein folding [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle checkpoint [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [IDA]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HAND1
Ehand1, Hxt, Th1, Thing1, bHLHa27, eHAND, RP23-268K22.4
heart and neural crest derivatives expressed transcript 1
GO Process (26)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- angiogenesis [IMP]
- cardiac left ventricle formation [ISO]
- cardiac right ventricle formation [ISO]
- cardiac septum morphogenesis [ISO]
- cartilage morphogenesis [IGI]
- cell differentiation [IGI]
- cell fate determination [NAS]
- determination of heart left/right asymmetry [IMP]
- embryonic heart tube development [IMP]
- embryonic heart tube formation [IMP]
- heart development [IGI, IMP]
- heart looping [IMP]
- heart morphogenesis [NAS, TAS]
- in utero embryonic development [IMP]
- mesenchyme development [IGI]
- mesoderm formation [IMP]
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [ISO]
- trophoblast giant cell differentiation [IDA, IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- bHLH transcription factor binding [IPI, ISO]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, IPI]
- sequence-specific DNA binding [IGI]
- transcription coactivator activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- bHLH transcription factor binding [IPI, ISO]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, IPI]
- sequence-specific DNA binding [IGI]
- transcription coactivator activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR ... [more]
Mol. Cell Proteomics Jul. 01, 2010; 9(7);1578-93 [Pubmed: 20368287]
Throughput
- High Throughput
Curated By
- BioGRID