BAIT
CSNK2A1
CK2A1, CKII, CSNK2A3
casein kinase 2, alpha 1 polypeptide
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- chaperone-mediated protein folding [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle checkpoint [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [IDA]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HTRA2
AI481710, Omi, Prss25, mnd2
HtrA serine peptidase 2
GO Process (20)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- cellular protein catabolic process [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to heat [ISO]
- cellular response to interferon-beta [ISO]
- cellular response to retinoic acid [ISO]
- forebrain development [IMP]
- intrinsic apoptotic signaling pathway [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- mitochondrion organization [IMP]
- negative regulation of cell death [ISO]
- neuron development [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- proteolysis [ISO]
- regulation of multicellular organism growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR ... [more]
Mol. Cell Proteomics Jul. 01, 2010; 9(7);1578-93 [Pubmed: 20368287]
Throughput
- High Throughput
Curated By
- BioGRID