BAIT
AGAP2
CENTG1, GGAP2, PIKE, RP11-571M6.8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (3)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NR4A1
GFRP1, Gfrp, Hbr-1, Hbr1, Hmr, N10, NGFI-B, NGFIB, NP10, TIS1, TR3, nur77
nuclear receptor subfamily 4, group A, member 1
GO Process (14)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- endothelial cell chemotaxis [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- response to inorganic substance [ISA]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR ... [more]
Mol. Cell Proteomics Jul. 01, 2010; 9(7);1578-93 [Pubmed: 20368287]
Throughput
- High Throughput
Curated By
- BioGRID