BAIT
AGAP2
CENTG1, GGAP2, PIKE, RP11-571M6.8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (3)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SIAH1A
AA982064, AI853500, Sinh1a
seven in absentia 1A
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- male meiosis I [IMP]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- post-embryonic development [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein catabolic process [ISO]
- protein destabilization [ISO]
- protein ubiquitination [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- regulation of multicellular organism growth [IMP]
- spermatogenesis [IMP]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR ... [more]
Mol. Cell Proteomics Jul. 01, 2010; 9(7);1578-93 [Pubmed: 20368287]
Throughput
- High Throughput
Curated By
- BioGRID