BIRC3
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- NIK/NF-kappaB signaling [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of necroptotic process [IBA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- positive regulation of protein ubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of RIG-I signaling pathway [TAS]
- regulation of apoptotic process [IMP]
- regulation of cysteine-type endopeptidase activity [TAS]
- regulation of inflammatory response [TAS]
- regulation of innate immune response [TAS]
- regulation of necroptotic process [IMP]
- regulation of nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- regulation of toll-like receptor signaling pathway [TAS]
- spindle assembly involved in mitosis [IBA]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IKBKE
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- NIK/NF-kappaB signaling [IDA]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- immune response [NAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- protein phosphorylation [IDA]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
IKKε-Mediated Tumorigenesis Requires K63-Linked Polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 Ubiquitin Ligase Complex.
IκB kinase ε (IKKε, IKBKE) is a key regulator of innate immunity and a breast cancer oncogene, amplified in ∼30% of breast cancers, that promotes malignant transformation through NF-κB activation. Here, we show that IKKε is modified and regulated by K63-linked polyubiquitination at lysine 30 and lysine 401. Tumor necrosis factor alpha and interleukin-1β stimulation induces IKKε K63-linked polyubiquitination over baseline ... [more]
Throughput
- Low Throughput
Additional Notes
- E1 ubiquitin activating enzyme (E-304)
- Ubc13 E2 enzyme
Curated By
- BioGRID