JAK2
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISS, TAS]
- STAT protein import into nucleus [ISS]
- actin filament polymerization [NAS]
- activation of JAK2 kinase activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISS]
- apoptotic process [ISS]
- blood coagulation [TAS]
- cell differentiation [ISS]
- cell migration [IBA]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [IDA, ISS, TAS]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA, ISS]
- extrinsic apoptotic signaling pathway [ISS]
- growth hormone receptor signaling pathway [IDA]
- histone H3-Y41 phosphorylation [IDA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-12-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- mammary gland epithelium development [ISS]
- mesoderm development [TAS]
- negative regulation of DNA binding [ISS]
- negative regulation of cell proliferation [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- positive regulation of growth hormone receptor signaling pathway [ISS]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [TAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of inflammatory response [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- response to interleukin-12 [IDA]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [IDA]
- signal transduction [ISS]
- tumor necrosis factor-mediated signaling pathway [IDA]
- tyrosine phosphorylation of STAT protein [IBA, ISS]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
Gene Ontology Cellular Component
EGFR
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [NAS]
- activation of phospholipase A2 activity by calcium-mediated signaling [TAS]
- activation of phospholipase C activity [TAS]
- axon guidance [TAS]
- cell proliferation [IDA]
- cell surface receptor signaling pathway [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to estradiol stimulus [IDA]
- epidermal growth factor receptor signaling pathway [IDA, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- learning or memory [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of protein catabolic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- ossification [NAS]
- peptidyl-tyrosine phosphorylation [IDA, IMP, TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA repair [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein autophosphorylation [IMP]
- protein insertion into membrane [TAS]
- regulation of nitric-oxide synthase activity [IDA]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- response to UV-A [IDA]
- response to stress [NAS]
- signal transduction [IDA, TAS]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- MAP kinase kinase kinase activity [NAS]
- actin filament binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [NAS]
- enzyme binding [IPI]
- epidermal growth factor-activated receptor activity [IDA, NAS]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IMP, TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- transmembrane signaling receptor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- MAP kinase kinase kinase activity [NAS]
- actin filament binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [NAS]
- enzyme binding [IPI]
- epidermal growth factor-activated receptor activity [IDA, NAS]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IMP, TAS]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- transmembrane signaling receptor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate one of the most well-studied signalling networks, there is not yet a genome-wide view of even the earliest step in this pathway: recruitment of proteins to the activated receptors. Here we use protein microarrays comprising virtually every Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain encoded ... [more]
Throughput
- High Throughput
Additional Notes
- interaction detected by probing protein array with labeled peptides
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JAK2 EGFR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EGFR JAK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EGFR JAK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| JAK2 EGFR | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1528246 |
Curated By
- BioGRID