BAIT

EGFR

ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
epidermal growth factor receptor
GO Process (42)
GO Function (15)
GO Component (13)

Gene Ontology Biological Process

Homo sapiens
PREY

NUMBL

CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
numb homolog (Drosophila)-like
Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Jones RB, Gordus A, Krall JA, MacBeath G

Although epidermal growth factor receptor (EGFR; also called ErbB1) and its relatives initiate one of the most well-studied signalling networks, there is not yet a genome-wide view of even the earliest step in this pathway: recruitment of proteins to the activated receptors. Here we use protein microarrays comprising virtually every Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain encoded ... [more]

Nature Jan. 12, 2006; 439(7073);168-74 [Pubmed: 16273093]

Throughput

  • High Throughput

Additional Notes

  • interaction detected by probing protein array with labeled peptides

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
EGFR NUMBL
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High0BioGRID
3511107

Curated By

  • BioGRID