BAIT
ZFYVE9
MADHIP, NSP, PPP1R173, SARA, SMADIP
zinc finger, FYVE domain containing 9
GO Process (6)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BMP4
BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
bone morphogenetic protein 4
GO Process (100)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP]
- BMP signaling pathway involved in heart induction [IMP]
- BMP signaling pathway involved in nephric duct formation [IDA]
- BMP signaling pathway involved in renal system segmentation [ISS]
- BMP signaling pathway involved in ureter morphogenesis [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPKK activity [IDA]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IDA]
- branching involved in ureteric bud morphogenesis [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- bronchus development [IDA]
- bud dilation involved in lung branching [IDA]
- cardiac septum development [TAS]
- chondrocyte differentiation [ISS]
- common-partner SMAD protein phosphorylation [IDA]
- deltoid tuberosity development [ISS]
- endocardial cushion development [TAS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in lung morphogenesis [IDA]
- epithelial tube branching involved in lung morphogenesis [IDA]
- extracellular matrix organization [TAS]
- glomerular capillary formation [ISS]
- hematopoietic progenitor cell differentiation [IDA]
- intermediate mesodermal cell differentiation [IDA]
- kidney development [IMP]
- lung alveolus development [IDA]
- lung morphogenesis [IDA]
- lymphoid progenitor cell differentiation [IMP]
- macrophage differentiation [IDA]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesonephros development [IEP]
- metanephric collecting duct development [ISS]
- monocyte differentiation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of T cell differentiation in thymus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway [IDA]
- negative regulation of branching involved in ureteric bud morphogenesis [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell proliferation involved in heart morphogenesis [IMP]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of glomerulus development [IDA]
- negative regulation of immature T cell proliferation in thymus [IMP]
- negative regulation of mesenchymal cell proliferation involved in ureter development [IDA]
- negative regulation of metanephric S-shaped body morphogenesis [IDA]
- negative regulation of metanephric comma-shaped body morphogenesis [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis [IGI]
- osteoblast differentiation [IDA]
- positive chemotaxis [IDA]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of DNA-dependent DNA replication [IDA]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of branching involved in lung morphogenesis [ISS]
- positive regulation of cardiac muscle fiber development [IMP]
- positive regulation of cartilage development [IDA]
- positive regulation of cell death [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epidermal cell differentiation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of kidney development [IDA]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IDA]
- protein localization to nucleus [IDA]
- pulmonary artery endothelial tube morphogenesis [IDA]
- regulation of cell fate commitment [IDA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of protein import into nucleus [IDA]
- renal system development [IEP]
- secondary heart field specification [IMP]
- smooth muscle tissue development [ISS]
- smoothened signaling pathway [IEP]
- specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway [IDA]
- steroid hormone mediated signaling pathway [IMP]
- telencephalon development [IDA]
- tendon cell differentiation [ISS]
- trachea development [IDA]
- type B pancreatic cell development [IDA]
- ureter epithelial cell differentiation [ISS]
- ureter smooth muscle cell differentiation [ISS]
- ureteric bud development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Functional proteomics mapping of a human signaling pathway.
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the interaction network, and cellular functional assays performed on newly identified proteins involved in a human signaling pathway. As a proof of principle, we studied the Smad signaling system, which is regulated by members of the transforming ... [more]
Genome Res. Jul. 01, 2004; 14(7);1324-32 [Pubmed: 15231748]
Throughput
- High Throughput
Curated By
- BioGRID