BAIT
PPP1CA
PP-1A, PP1A, PP1alpha, PPP1A
protein phosphatase 1, catalytic subunit, alpha isozyme
GO Process (8)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HEYL
HESR3, HEY3, HRT3, bHLHb33
hes-related family bHLH transcription factor with YRPW motif-like
GO Process (15)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- Notch signaling pathway [IDA, TAS]
- atrioventricular valve morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac ventricle morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- mesenchymal cell development [ISS]
- negative regulation of androgen receptor activity [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- pulmonary valve morphogenesis [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- AF-1 domain binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [NAS]
- AF-1 domain binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [NAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Functional proteomics mapping of a human signaling pathway.
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the interaction network, and cellular functional assays performed on newly identified proteins involved in a human signaling pathway. As a proof of principle, we studied the Smad signaling system, which is regulated by members of the transforming ... [more]
Genome Res. Jul. 01, 2004; 14(7);1324-32 [Pubmed: 15231748]
Throughput
- High Throughput
Curated By
- BioGRID