BAIT
INPP5D
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
inositol polyphosphate-5-phosphatase, 145kDa
GO Process (9)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- inositol phosphate metabolic process [TAS]
- leukocyte migration [TAS]
- phosphate-containing compound metabolic process [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DAB1
RP6-239D12.2
Dab, reelin signal transducer, homolog 1 (Drosophila)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2.
SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial sensor that activates proinflammatory and antimicrobial responses upon bacterial invasion. We observed that SHIP-1 decreases NOD2-induced ... [more]
PLoS ONE Jul. 21, 2012; 7(7);e41005 [Pubmed: 22815893]
Throughput
- Low Throughput
Curated By
- BioGRID