STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [ISO]
- intracellular protein transport [IBA]
- neurotransmitter transport [TAS]
- positive regulation of exocytosis [IDA]
- positive regulation of neurotransmitter secretion [IMP]
- regulation of exocytosis [IMP]
- response to gravity [IDA]
- secretion by cell [ISO]
- synaptic vesicle docking [IEP]
- synaptic vesicle fusion to presynaptic membrane [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
Gene Ontology Cellular Component
- SNARE complex [ISO, ISS]
- actomyosin [IDA]
- cell [ISO]
- integral component of membrane [NAS]
- intracellular organelle [IDA]
- membrane [ISO]
- neuron projection [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- secretory granule [IDA]
- synaptic vesicle [IBA, ISO]
- synaptic vesicle membrane [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
KCNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
It is thought that the voltage-dependent potassium channel subunit Kv2.1 (Kv2.1) regulates insulin secretion by controlling beta cell electrical excitability. However, this role of Kv2.1 in human insulin secretion has been questioned. Interestingly, Kv2.1 can also regulate exocytosis through direct interaction of its C-terminus with the soluble NSF attachment receptor (SNARE) protein, syntaxin 1A. We hypothesised that this interaction mediates ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
KCNB1 STX1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID