BAIT
JAK2
Fd17
Janus kinase 2
GO Process (80)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- JAK-STAT cascade [IDA, IMP, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, IMP, ISO]
- STAT protein import into nucleus [IDA]
- activation of JAK2 kinase activity [IDA]
- activation of MAPKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IDA]
- axon regeneration [ISO]
- cell differentiation [IMP]
- cell migration [IBA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cytokine-mediated signaling pathway [IMP, ISO, TAS]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO]
- hormone-mediated signaling pathway [ISO]
- host programmed cell death induced by symbiont [IDA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- mammary gland epithelium development [IMP]
- mineralocorticoid receptor signaling pathway [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of neuron apoptotic process [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell activation [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of growth hormone receptor signaling pathway [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- protein autophosphorylation [IDA, ISO]
- regulation of cell adhesion [IBA]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to granulocyte macrophage colony-stimulating factor [NAS]
- response to hydroperoxide [ISO]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [IDA]
- response to oxidative stress [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [IDA, IMP]
- tyrosine phosphorylation of Stat1 protein [ISO]
- tyrosine phosphorylation of Stat3 protein [ISO]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
STAT5B
RP23-279L23.3
signal transducer and activator of transcription 5B
GO Process (63)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [IMP]
- JAK-STAT cascade [IDA, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- Peyer's patch development [IGI]
- T cell differentiation in thymus [IGI]
- T cell homeostasis [IGI]
- acute-phase response [ISO]
- allantoin metabolic process [IMP]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to growth factor stimulus [IDA]
- cellular response to hormone stimulus [ISO]
- citrate metabolic process [IMP]
- creatine metabolic process [IMP]
- creatinine metabolic process [IMP]
- cytokine-mediated signaling pathway [IDA]
- development of secondary female sexual characteristics [IMP]
- development of secondary male sexual characteristics [IGI, IMP]
- fatty acid metabolic process [IMP]
- female pregnancy [IGI, IMP]
- isoleucine metabolic process [IMP]
- lactation [IMP]
- lipid storage [IGI]
- liver development [ISO]
- luteinization [IGI, ISO]
- natural killer cell differentiation [IGI]
- negative regulation of apoptotic process [IGI]
- negative regulation of erythrocyte differentiation [IGI]
- oxaloacetate metabolic process [IMP]
- positive regulation of B cell differentiation [IGI]
- positive regulation of activated T cell proliferation [IGI, IMP]
- positive regulation of cell proliferation [IGI]
- positive regulation of cellular component movement [ISO]
- positive regulation of gamma-delta T cell differentiation [IGI]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-2 biosynthetic process [IGI]
- positive regulation of lymphocyte differentiation [IGI]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of natural killer cell differentiation [IMP]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- positive regulation of natural killer cell proliferation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- progesterone metabolic process [IGI]
- prolactin signaling pathway [IDA]
- regulation of cell adhesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of multicellular organism growth [IDA]
- regulation of steroid metabolic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [ISO]
- response to estradiol [ISO]
- response to interleukin-15 [IMP]
- response to interleukin-2 [IMP]
- response to interleukin-4 [IMP]
- response to lipopolysaccharide [ISO]
- response to peptide hormone [ISO]
- sex differentiation [IMP]
- signal transduction [IGI]
- succinate metabolic process [IMP]
- taurine metabolic process [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- valine metabolic process [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- glucocorticoid receptor binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- signal transducer activity [IGI]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- glucocorticoid receptor binding [ISO]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- signal transducer activity [IGI]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.
Insulin stimulates signal transducer and activator of transcription 5 (Stat5) activation in insulin receptor (IR)-overexpressing cell lines and in insulin target tissues of mice. Stat5b and insulin receptor substrate 1 (IRS-1) interact with the same autophosphorylation site in the IR [phosphotyrosine (pY) 972] in yeast two-hybrid assays, and the IR phosphorylates Stat5b in vitro. These data suggest that Stat5 proteins ... [more]
Mol. Endocrinol. Dec. 01, 2002; 16(12);2764-79 [Pubmed: 12456798]
Throughput
- Low Throughput
Curated By
- BioGRID