ATR
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA repair [TAS]
- DNA replication [TAS]
- cell cycle [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to UV [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair via homologous recombination [IBA]
- multicellular organismal development [TAS]
- negative regulation of DNA replication [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- protein autophosphorylation [IDA]
- replicative senescence [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BID
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IDA]
- establishment of protein localization to membrane [ISO]
- extrinsic apoptotic signaling pathway [IMP]
- hepatocyte apoptotic process [IGI]
- mitochondrial outer membrane permeabilization [IGI]
- positive regulation of apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein homooligomerization [IDA, ISO]
- positive regulation of protein oligomerization [ISO]
- positive regulation of release of cytochrome c from mitochondria [IGI, ISO]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of cell proliferation [IMP]
- regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IDA, IMP, ISO]
- signal transduction in response to DNA damage [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A role for proapoptotic BID in the DNA-damage response.
The BCL-2 family of apoptotic proteins encompasses key regulators proximal to irreversible cell damage. The BH3-only members of this family act as sentinels, interconnecting specific death signals to the core apoptotic pathway. Our previous data demonstrated a role for BH3-only BID in maintaining myeloid homeostasis and suppressing leukemogenesis. In the absence of Bid, mice accumulate chromosomal aberrations and develop a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATR BID | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 854669 |
Curated By
- BioGRID