BAIT
MLH1
COCA2, FCC2, HNPCC, HNPCC2, hMLH1
mutL homolog 1
GO Process (3)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GSTP1
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
glutathione S-transferase pi 1
GO Process (30)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- central nervous system development [TAS]
- common myeloid progenitor cell proliferation [ISS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of MAPK cascade [NAS]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [ISS]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IC]
- nitric oxide storage [NAS]
- positive regulation of superoxide anion generation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of stress-activated MAPK cascade [ISS]
- response to reactive oxygen species [ISS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.
The involvement of MLH1 in several mismatch repair-independent cellular processes has been reported. In an attempt to gain further insight into the protein's cellular functions, we screened for novel interacting partners of MLH1 utilizing a bacterial two-hybrid system. Numerous unknown interacting proteins were identified, suggesting novel biological roles of MLH1. The network of MLH1 and its partner proteins involves a ... [more]
Proteomics Sep. 01, 2010; 10(18);3343-55 [Pubmed: 20706999]
Throughput
- Low Throughput
Curated By
- BioGRID