BAIT
MLH1
COCA2, FCC2, HNPCC, HNPCC2, hMLH1
mutL homolog 1
GO Process (3)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VAMP8
EDB, VAMP-8
vesicle-associated membrane protein 8
GO Process (13)
GO Function (3)
GO Component (15)
Gene Ontology Biological Process
- autophagic vacuole fusion [IMP]
- endocytosis [IBA]
- eosinophil degranulation [IMP]
- exocytosis [IBA]
- membrane organization [TAS]
- mucus secretion [IMP]
- negative regulation of secretion by cell [IDA]
- neutrophil degranulation [IMP]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of protein localization to plasma membrane [IDA]
- vesicle fusion [IBA]
- viral entry into host cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- membrane [IDA]
- mucin granule [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- recycling endosome [IDA]
- secretory granule membrane [IDA, TAS]
- vesicle [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1.
The involvement of MLH1 in several mismatch repair-independent cellular processes has been reported. In an attempt to gain further insight into the protein's cellular functions, we screened for novel interacting partners of MLH1 utilizing a bacterial two-hybrid system. Numerous unknown interacting proteins were identified, suggesting novel biological roles of MLH1. The network of MLH1 and its partner proteins involves a ... [more]
Proteomics Sep. 01, 2010; 10(18);3343-55 [Pubmed: 20706999]
Throughput
- Low Throughput
Curated By
- BioGRID