BAIT
GRIN2A
EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, RP11-297M9.2
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPTAN1
EIEE5, NEAS, SPTA2
spectrin, alpha, non-erythrocytic 1
GO Process (3)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.
The N-methyl-D-aspartate receptor (NMDA-R) and brain spectrin, a protein that links membrane proteins to the actin cytoskeleton, are major components of post-synaptic densities (PSDs). Since the activity of the NMDA-R channel is dependent on the integrity of actin and leads to calpain-mediated spectrin breakdown, we have investigated whether the actin-binding spectrin may interact directly with NMDA-Rs. Spectrin is reported here ... [more]
EMBO J. Jul. 15, 1998; 17(14);3931-9 [Pubmed: 9670010]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GRIN2A SPTAN1 | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID