PREY

GRIN1

GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1, RP11-350O14.1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Homo sapiens

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.

Wechsler A, Teichberg VI

The N-methyl-D-aspartate receptor (NMDA-R) and brain spectrin, a protein that links membrane proteins to the actin cytoskeleton, are major components of post-synaptic densities (PSDs). Since the activity of the NMDA-R channel is dependent on the integrity of actin and leads to calpain-mediated spectrin breakdown, we have investigated whether the actin-binding spectrin may interact directly with NMDA-Rs. Spectrin is reported here ... [more]

EMBO J. Jul. 15, 1998; 17(14);3931-9 [Pubmed: 9670010]

Throughput

  • Low Throughput

Additional Notes

  • phosphorlation decreases binding to spectrin

Curated By

  • BioGRID