BAIT

MAP1LC3A

ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, RP11-346K17.1
microtubule-associated protein 1 light chain 3 alpha
Autophagy Project
Homo sapiens
PREY

ASAP2

AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
GO Process (1)
GO Function (2)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.

Wang BS, Liu YZ, Yang Y, Zhang Y, Hao JJ, Yang H, Wang XM, Zhang ZQ, Zhan QM, Wang MR

There have been multiple lines of evidence suggesting that autophagy selectively targets signalling proteins and regulates cancer cell signalling in addition to bulk clearance of long-lived proteins and organelles. Protein degradation through autophagy requires receptor protein LC3B to sequester the substrates into the autophagosome. In the present study, we screened LC3B (light-chain 3B)-binding partners and identified autophagic substrates in cancer ... [more]

Clin. Sci. Feb. 01, 2013; 124(3);203-14 [Pubmed: 22963397]

Throughput

  • Low Throughput

Curated By

  • BioGRID