BAIT

MBP

C76307, Hmbpr, R75289, golli-mbp, mld, shi

myelin basic protein

GO Process (3)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

membrane organization [IDA]

myelination [IDA]

response to toxic substance [IDA]

Gene Ontology Molecular Function

protease binding [IPI]

Gene Ontology Cellular Component

cell periphery [IDA]

cell projection [IDA]

internode region of axon [IDA]

myelin sheath [IDA]

neuronal cell body [IDA]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

HCLS1

CTTNL, HS1, lckBP1, p75

hematopoietic cell-specific Lyn substrate 1

GO Process (17)

GO Function (3)

GO Component (3)

Gene Ontology Biological Process

cellular response to cytokine stimulus [IMP]

erythrocyte differentiation [ISS]

intracellular signal transduction [TAS]

negative regulation of leukocyte apoptotic process [IMP]

positive regulation of actin cytoskeleton reorganization [IC]

positive regulation of cell proliferation [ISS]

positive regulation of granulocyte differentiation [IMP]

positive regulation of peptidyl-serine phosphorylation [IMP]

positive regulation of peptidyl-tyrosine phosphorylation [IMP]

positive regulation of phosphatidylinositol 3-kinase signaling [IMP]

positive regulation of protein kinase B signaling [IMP]

positive regulation of transcription factor import into nucleus [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP]

positive regulation of tyrosine phosphorylation of STAT protein [ISS]

regulation of actin filament polymerization [IMP]

regulation of transcription, DNA-templated [TAS]

response to hormone [ISS]

Gene Ontology Molecular Function

RNA polymerase II transcription factor binding [IPI]
protein binding [IPI]
protein kinase binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA, ISS]

nucleus [IDA, ISS]

transcription factor complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

Polverini E, Rangaraj G, Libich DS, Boggs JM, Harauz G

Myelin basic protein (MBP) is a multifunctional protein involved in maintaining the stability and integrity of the myelin sheath by a variety of interactions with membranes and with cytoskeletal and other proteins. A central segment of MBP is highly conserved in mammals and consists of a membrane surface-associated amphipathic alpha-helix, immediately followed by a proline-rich segment that we hypothesize is ... [more]

Biochemistry Jan. 08, 2008; 47(1);267-82 [Pubmed: 18067320]

Throughput

Low Throughput

Additional Notes

recombinant murine MBP binds to the SH3 domain on a peptide array

Curated By

BioGRID