BAIT
MBP
C76307, Hmbpr, R75289, golli-mbp, mld, shi
myelin basic protein
GO Process (3)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RASA1
CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
RAS p21 protein activator (GTPase activating protein) 1
GO Process (14)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- embryo development [ISS]
- intracellular signal transduction [NAS]
- mitotic cytokinesis [ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell-matrix adhesion [IDA]
- negative regulation of neuron apoptotic process [ISS]
- positive regulation of Ras GTPase activity [IBA]
- regulation of RNA metabolic process [NAS]
- regulation of actin filament polymerization [IDA]
- regulation of cell shape [NAS]
- signal transduction [IDA]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.
Myelin basic protein (MBP) is a multifunctional protein involved in maintaining the stability and integrity of the myelin sheath by a variety of interactions with membranes and with cytoskeletal and other proteins. A central segment of MBP is highly conserved in mammals and consists of a membrane surface-associated amphipathic alpha-helix, immediately followed by a proline-rich segment that we hypothesize is ... [more]
Biochemistry Jan. 08, 2008; 47(1);267-82 [Pubmed: 18067320]
Throughput
- Low Throughput
Additional Notes
- recombinant murine MBP binds to the SH3 domain on a peptide array
Curated By
- BioGRID