BAIT
RPSA
37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40
ribosomal protein SA
GO Process (17)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- rRNA export from nucleus [IBA]
- ribosomal small subunit assembly [IBA]
- translation [IBA, IC, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BRCA1
BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
breast cancer 1, early onset
GO Process (44)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [TAS]
- DNA repair [TAS]
- G2 DNA damage checkpoint [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to tumor necrosis factor [IMP]
- chordate embryonic development [IBA]
- chromosome segregation [IMP]
- dosage compensation by inactivation of X chromosome [IBA]
- double-strand break repair [IMP, TAS]
- double-strand break repair via homologous recombination [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of centriole replication [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fatty acid biosynthetic process [IMP]
- negative regulation of histone H3-K9 methylation [IDA]
- negative regulation of histone acetylation [IBA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K9 acetylation [IDA]
- positive regulation of histone H4-K16 acetylation [IDA]
- positive regulation of histone H4-K20 methylation [IDA]
- positive regulation of histone acetylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [NAS, TAS]
- positive regulation vascular endothelial growth factor production [IMP]
- postreplication repair [IDA]
- protein K6-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell proliferation [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase III promoter [TAS]
- response to estrogen [IDA]
- response to ionizing radiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Nucleolar exit of RNF8 and BRCA1 in response to DNA damage.
The induction of DNA double-strand breaks (DSBs) elicits a plethora of responses that redirect many cellular functions to the vital task of repairing the injury, collectively known as the DNA damage response (DDR). We have found that, in the absence of DNA damage, the DSB repair factors RNF8 and BRCA1 are associated with the nucleolus. Shortly after exposure of cells ... [more]
Exp. Cell Res. Nov. 01, 2012; 318(18);2365-76 [Pubmed: 22814251]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRCA1 RPSA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID