Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.

Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K

Nucleophosmin (NPM)/B23 has been implicated in the regulation of centrosome duplication. NPM/B23 localizes between two centrioles in the unduplicated centrosome. Upon phosphorylation on Thr(199) by cyclin-dependent kinase 2 (CDK2)/cyclin E, the majority of centrosomal NPM/B23 dissociates from centrosomes, but some NPM/B23 phosphorylated on Thr(199) remains at centrosomes. It has been shown that Thr(199) phosphorylation of NPM/B23 is critical for the ... [more]

Mol. Cell. Biol. Dec. 01, 2006; 26(23);9016-34 [Pubmed: 17015463]

Throughput

  • Low Throughput

Curated By

  • BioGRID