MAPK8IP3
Gene Ontology Biological Process
- JNK cascade [IDA]
- activation of JUN kinase activity [IDA]
- axon guidance [IMP]
- forebrain development [IMP]
- in utero embryonic development [IMP]
- lung alveolus development [IMP]
- lung morphogenesis [IMP]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of neuron differentiation [ISO]
- positive regulation of signal transduction [IPI]
- post-embryonic development [IMP]
- protein localization [IMP]
- regulation of JNK cascade [IDA]
- regulation of gene expression [IDA]
- respiratory gaseous exchange [IMP]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP3K5
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [IDA, ISO]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to reactive nitrogen species [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA, ISO]
- positive regulation of apoptotic process [IDA, ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of protein phosphorylation [ISO]
- programmed necrotic cell death [IMP]
- protein phosphorylation [IDA, ISO]
- regulation of cell death [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase kinase kinase activity [IDA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- ATP binding [ISO]
- MAP kinase kinase kinase activity [IDA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
The c-Jun NH2-terminal kinase (JNK)-interacting protein (JIP) group of scaffold proteins (JIP1, JIP2, and JIP3) can interact with components of the JNK signaling pathway and potently activate JNK. Here we describe the identification of a fourth member of the JIP family. The primary sequence of JIP4 is most closely related to that of JIP3. Like other members of the JIP ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID