BAIT
TTI1
FMP47, YKL033W
Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
GO Process (0)
GO Function (0)
GO Component (3)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
TFC6
transcription factor TFIIIC subunit TFC6, tau 91, L000004492, YDR362C
Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
GO Process (3)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding [IDA]
- RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity [IDA]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components.
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and ... [more]
PLoS Genet. Apr. 01, 2011; 7(4);e1002057 [Pubmed: 21552543]
Quantitative Score
- -0.312453667 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- interaction score < -0.3, p-value > 0.05; tti1-1 allele
Curated By
- BioGRID