HOMER3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM5
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- activation of MAPKKK activity [ISO]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [ISO]
- learning [IMP]
- locomotory behavior [IGI, IMP]
- negative regulation of locomotion [ISO]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA, ISO]
- protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [ISO]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.
Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer 1a), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID