FGF2
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- angiogenesis [IDA, IGI]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cardiac muscle cell proliferation [TAS]
- cell migration involved in sprouting angiogenesis [ISO]
- chondroblast differentiation [ISO]
- corticotropin hormone secreting cell differentiation [IDA]
- embryo development ending in birth or egg hatching [ISO]
- fibroblast growth factor receptor signaling pathway [IGI, ISO]
- glial cell differentiation [IMP]
- hyaluronan catabolic process [ISO]
- inositol phosphate biosynthetic process [ISO]
- lung development [IDA, IGI]
- mammary gland epithelial cell differentiation [IDA]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of fibroblast migration [ISO]
- negative regulation of wound healing [ISO]
- organ induction [IDA]
- phosphatidylinositol biosynthetic process [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of angiogenesis [IDA, IGI, ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell differentiation [IDA]
- positive regulation of cell fate specification [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO, TAS]
- regulation of cell cycle [IDA]
- regulation of retinal cell programmed cell death [IDA]
- release of sequestered calcium ion into cytosol [ISO]
- response to axon injury [IMP]
- stem cell development [IMP]
- substantia nigra development [IMP]
- thyroid-stimulating hormone-secreting cell differentiation [IDA]
Gene Ontology Molecular Function
FGFRL1
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISA]
- diaphragm development [IMP]
- fibroblast growth factor receptor signaling pathway [ISO]
- heart valve morphogenesis [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IC]
- peptidyl-tyrosine phosphorylation [ISO]
- skeletal system development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of a new fibroblast growth factor receptor, FGFR5.
A novel fibroblast growth factor receptor (FGFR), designated FGFR5, was identified from an EST database of a murine lymph node stromal cell cDNA library. The EST has approximately 32% identity to the extracellular domain of FGFR1-4. Library screening with this EST identified two full-length alternative transcripts which we designated as FGFR5 beta and FGFR5 gamma. The main difference between these ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGFRL1 FGF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID