BAIT
FGF2
Fgf-2, Fgfb, bFGF, DN-452A22.6
fibroblast growth factor 2
GO Process (51)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- angiogenesis [IDA, IGI]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cardiac muscle cell proliferation [TAS]
- cell migration involved in sprouting angiogenesis [ISO]
- chondroblast differentiation [ISO]
- corticotropin hormone secreting cell differentiation [IDA]
- embryo development ending in birth or egg hatching [ISO]
- fibroblast growth factor receptor signaling pathway [IGI, ISO]
- glial cell differentiation [IMP]
- hyaluronan catabolic process [ISO]
- inositol phosphate biosynthetic process [ISO]
- lung development [IDA, IGI]
- mammary gland epithelial cell differentiation [IDA]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of fibroblast migration [ISO]
- negative regulation of wound healing [ISO]
- organ induction [IDA]
- phosphatidylinositol biosynthetic process [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of angiogenesis [IDA, IGI, ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell differentiation [IDA]
- positive regulation of cell fate specification [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO, TAS]
- regulation of cell cycle [IDA]
- regulation of retinal cell programmed cell death [IDA]
- release of sequestered calcium ion into cytosol [ISO]
- response to axon injury [IMP]
- stem cell development [IMP]
- substantia nigra development [IMP]
- thyroid-stimulating hormone-secreting cell differentiation [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
FGFR2
AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFR, KGFRTr, svs
fibroblast growth factor receptor 2
GO Process (102)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- angiogenesis [IGI]
- axonogenesis [IMP]
- bone development [IMP]
- bone mineralization [IMP]
- bone morphogenesis [IMP]
- branch elongation involved in salivary gland morphogenesis [IGI, IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- branching involved in prostate gland morphogenesis [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- branching morphogenesis of a nerve [IMP]
- bud elongation involved in lung branching [IMP]
- cell fate commitment [IDA]
- cell-cell signaling [IMP]
- coronal suture morphogenesis [IMP]
- digestive tract development [IMP]
- embryonic cranial skeleton morphogenesis [ISO]
- embryonic digestive tract morphogenesis [IMP]
- embryonic organ development [IMP]
- embryonic organ morphogenesis [IMP]
- embryonic pattern specification [IMP]
- endodermal digestive tract morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- epithelial cell differentiation [IMP]
- epithelial cell proliferation [IMP]
- epithelial cell proliferation involved in salivary gland morphogenesis [IGI, IMP]
- epithelial to mesenchymal transition [ISO]
- epithelial tube branching involved in lung morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IGI, IMP, ISO]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [IMP]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [IMP]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [IMP]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [IMP]
- gland morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- in utero embryonic development [IGI, IMP]
- inner ear morphogenesis [IMP]
- lacrimal gland development [IMP]
- lateral sprouting from an epithelium [IMP]
- lens fiber cell development [IGI, IMP]
- limb bud formation [IMP]
- lung alveolus development [IGI, IMP]
- lung development [IGI, IMP]
- lung lobe morphogenesis [IMP]
- lung-associated mesenchyme development [IGI, IMP]
- mammary gland bud formation [IMP]
- membranous septum morphogenesis [IMP]
- mesenchymal cell differentiation [IGI]
- mesenchymal cell differentiation involved in lung development [IGI]
- mesenchymal cell proliferation involved in lung development [IMP]
- midbrain development [IGI]
- morphogenesis of embryonic epithelium [IMP]
- multicellular organism growth [IMP]
- negative regulation of cell proliferation [IGI]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitosis [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuromuscular junction development [IMP]
- odontogenesis [IMP]
- orbitofrontal cortex development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- otic vesicle formation [IMP]
- outflow tract septum morphogenesis [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI, IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell division [IMP]
- positive regulation of cell proliferation [IGI, IMP, ISO]
- positive regulation of epithelial cell proliferation [IGI]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [IMP]
- positive regulation of mesenchymal cell proliferation [IGI]
- positive regulation of phospholipase activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-embryonic development [IMP]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- prostate epithelial cord elongation [IMP]
- prostate gland morphogenesis [IMP]
- protein autophosphorylation [ISO]
- pyramidal neuron development [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell fate commitment [IMP]
- regulation of cell proliferation [IMP]
- regulation of epithelial cell proliferation [IMP]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of morphogenesis of a branching structure [IMP]
- regulation of multicellular organism growth [IMP]
- regulation of smooth muscle cell differentiation [IMP]
- regulation of smoothened signaling pathway [IMP]
- reproductive structure development [IMP]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [IMP]
- synaptic vesicle transport [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of a new fibroblast growth factor receptor, FGFR5.
A novel fibroblast growth factor receptor (FGFR), designated FGFR5, was identified from an EST database of a murine lymph node stromal cell cDNA library. The EST has approximately 32% identity to the extracellular domain of FGFR1-4. Library screening with this EST identified two full-length alternative transcripts which we designated as FGFR5 beta and FGFR5 gamma. The main difference between these ... [more]
Gene Jun. 27, 2001; 271(2);171-82 [Pubmed: 11418238]
Throughput
- Low Throughput
Curated By
- BioGRID