SOD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP7A
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP metabolic process [IMP]
- T-helper cell differentiation [IMP]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cartilage development [IMP]
- catecholamine metabolic process [IMP]
- cellular copper ion homeostasis [IGI, IMP, ISO]
- central nervous system neuron development [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- collagen fibril organization [IMP]
- copper ion export [IDA, IMP]
- copper ion import [IMP]
- copper ion transport [IDA, IMP, ISO]
- dendrite morphogenesis [IMP]
- detoxification of copper ion [IMP]
- dopamine metabolic process [IMP]
- elastic fiber assembly [IMP]
- elastin biosynthetic process [IMP]
- epinephrine metabolic process [IMP]
- extracellular matrix organization [IMP]
- hair follicle morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- locomotory behavior [IMP]
- lung alveolus development [IMP]
- mitochondrion organization [IMP]
- negative regulation of metalloenzyme activity [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neuron projection morphogenesis [IMP]
- norepinephrine biosynthetic process [IMP]
- norepinephrine metabolic process [IMP]
- peptidyl-lysine modification [IMP]
- pigmentation [IMP]
- plasma membrane copper ion transport [ISO]
- positive regulation of catalytic activity [IDA, IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of oxidoreductase activity [ISO]
- pyramidal neuron development [IMP]
- regulation of gene expression [IMP]
- regulation of oxidative phosphorylation [IMP]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IMP]
- response to copper ion [ISO]
- serotonin metabolic process [IMP]
- skin development [IMP]
- tryptophan metabolic process [IMP]
- tyrosine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell [IGI]
- cytoplasmic vesicle [IDA]
- endoplasmic reticulum [ISO]
- integral component of membrane [ISO]
- late endosome [ISO]
- membrane [IDA, ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [ISO]
- trans-Golgi network [IDA, ISO]
- trans-Golgi network transport vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.
Extracellular superoxide dismutase (SOD3), a secretory copper enzyme, plays an important role in atherosclerosis and hypertension by modulating the levels of extracellular superoxide anion (O2*-) in the vasculature. Little is known about the mechanisms by which SOD3 obtains its catalytic copper cofactor. Menkes ATPase (MNK) has been shown to transport cytosolic copper to the secretory pathway in nonvascular cells. We ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID