BAIT

CFTR

ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

GO Process (9)

GO Function (9)

GO Component (10)

Gene Ontology Biological Process

cellular response to cAMP [ISS]

chloride transmembrane transport [IDA, ISS, NAS, TAS]

intracellular pH elevation [ISS]

membrane hyperpolarization [ISS]

positive regulation of voltage-gated chloride channel activity [IDA]

respiratory gaseous exchange [TAS]

sperm capacitation [ISS]

transmembrane transport [TAS]

transport [TAS]

Gene Ontology Molecular Function

ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
PDZ domain binding [IDA]
bicarbonate transmembrane transporter activity [ISS]
channel-conductance-controlling ATPase activity [NAS]
chloride channel activity [IDA]
chloride channel inhibitor activity [IDA]
chloride transmembrane transporter activity [ISS]
enzyme binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

apical plasma membrane [IDA]

basolateral plasma membrane [NAS]

cell surface [IDA]

cytoplasm [IDA]

early endosome [IDA]

endoplasmic reticulum Sec complex [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA, TAS]

protein complex [IDA]

recycling endosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

UBE3A

ANCR, AS, E6-AP, EPVE6AP, HPVE6A

ubiquitin protein ligase E3A

Human Papilloma Virus (HPV) Project

GO Process (9)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

androgen receptor signaling pathway [IBA]

brain development [TAS]

protein K48-linked ubiquitination [IDA]

protein autoubiquitination [IDA]

protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]

proteolysis [TAS]

regulation of circadian rhythm [IMP]

regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

protein binding [IPI]
ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IBA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE

The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum (ER). Cell-surface rescue of the most common ... [more]

Cell Nov. 17, 2006; 127(4);803-15 [Pubmed: 17110338]

Throughput

High Throughput

Ontology Terms

calu-3 cell (BTO:0002750) [lung adenocarcinoma (DOID:3910)]

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
UBE3A CFTR	Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.	Mishra A (2009)	Low	-	BioGRID	-

Curated By

BioGRID