BAIT
CFTR
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
GO Process (9)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- cellular response to cAMP [ISS]
- chloride transmembrane transport [IDA, ISS, NAS, TAS]
- intracellular pH elevation [ISS]
- membrane hyperpolarization [ISS]
- positive regulation of voltage-gated chloride channel activity [IDA]
- respiratory gaseous exchange [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AB1
90kDa, AL022974, C81438, Hsp84, Hsp84-1, Hsp90, Hspcb
heat shock protein 90 alpha (cytosolic), class B member 1
GO Process (7)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- cellular response to interleukin-4 [IDA]
- negative regulation of neuron apoptotic process [ISO]
- placenta development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum (ER). Cell-surface rescue of the most common ... [more]
Cell Nov. 17, 2006; 127(4);803-15 [Pubmed: 17110338]
Throughput
- High Throughput
Ontology Terms
- cell line: calu-3 cell (BTO:0002750) [lung adenocarcinoma (DOID:3910)]
- cell line: colorectal adenocarcinoma cell line (BTO:0001914) [colorectal cancer (DOID:9256)]
Additional Notes
- T84 cell
Curated By
- BioGRID